974 FUNCTIONAL P53 DETERMINES DOCETAXEL SENSITIVITY IN PROSTATE CANCER CELLS
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چکیده
منابع مشابه
Identification, characterization and targeting of Docetaxel-resistant prostate cancer cells.
en with castration-resistant prostate cancer exhibit resistance to chemotherapeutic agents such as Docetaxel. Defining the mechanisms of resistance to Docetaxel is critical for treating advanced disease. In a new study, Carlos Cordon-Cardo and colleagues determine that Docetaxel-resistant prostate cancer cells rely on the Notch and Hedgehog signaling pathways for their survival. These findings ...
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Prostate cancer continues to represent a burgeoning medical problem in the United States. Recent studies suggest that gossypol, a bioactive phytochemical produced by cotton plants, is a promising agent against prostate cancer. The current studies were undertaken to examine the chemotherapeutic efficacy of gossypol on human prostate cancer cell lines and prostate tumor-initiating cells. Gossypol...
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Background: In prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 (MRP1) by an effect on promoter region. Objectives: The objective of this study was to identify association...
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ژورنال
عنوان ژورنال: Journal of Urology
سال: 2013
ISSN: 0022-5347,1527-3792
DOI: 10.1016/j.juro.2013.02.556